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包亮亮,加依娜.拉兹别克,张燕,等.密切接触者人群队列肺结核发现策略的成本-效用分析*[J].中国卫生经济,2023,42(4):65-69.[点击复制] |
BAO Liang-liang,Jiayina Lazibieke,ZHANG Yan,et al.Cost-effectiveness Analysis of Tuberculosis Detection Strategy Based on Close Contact Cohort[J].CHINESE HEALTH ECONOMICS,2023,42(4):65-69.[点击复制] |
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| 密切接触者人群队列肺结核发现策略的成本-效用分析* |
| 包亮亮,加依娜.拉兹别克,张燕,胥婉婷,毛宏凯,玛依沙.达肯,夏文俊,曹明芹 |
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| (新疆医科大学公共卫生学院 乌鲁木齐 830011) |
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| 摘要: |
| 目的：对密切接触者主动筛查策略进行成本-效用分析，为肺结核的早期发现与防治策略提供科学依据。方法： 建立密切接触者筛查策略的决策树-Markov模型，比较病例被动筛查策略与病例主动筛查策略的成本-效用。结果：与病例被动筛查策略相比，采用终身一次的病例主动筛查策略、终身两次不连续的病例主动筛查策略、每年一次的病例主动筛查策略的潜伏感染发生率、结核病发病率、死亡率均依次降低，并且每增加1QALY的花费分别为8973.3元、8995.0元、10801.2 元，均低于WTP阈值标准，3种病例主动筛查策略均具有成本-效用优势。结论：对密切接触者连续开展主动筛查具有较高的成本-效用价值，是一项经济有效的公共卫生干预措施。 |
| 关键词: 肺结核 密切接触者 病例主动筛查 病例被动筛查 成本-效用分析 |
| DOI： |
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| 基金项目:国家自然科学基金项目(82060622，U1903123) |
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| Cost-effectiveness Analysis of Tuberculosis Detection Strategy Based on Close Contact Cohort |
| BAO Liang-liang,Jiayina Lazibieke,ZHANG Yan,XU Wan-ting,MAO Hong-kai,MA YISHA Da-ken,XIA Wen-jun,CAO Mng-Qin |
| (School of Public Health,Xinjiang Medical University,Urumqi 830011 ,China) |
| Abstract: |
| Objective: To analyze the cost-effectiveness of the active screening strategy for close contacts，and provide scientific basis for the early detection and prevention of tuberculosis. Methods: The decision tree Markov model of close contact screening strategy was established to compare the cost-effectiveness of passive screening strategy and active screening strategy. Results: Compared with the passive screening strategy，the incidence of latent infection，incidence rate of tuberculosis，and mortality of the active screening strategy once a year，the discontinuous active screening strategy twice a lifetime and the active screening strategy once a year all decreased in turn. The cost of each additional 1QALY was 8973.3 yuan8995 yuan，and 10801.2 yuan，lower than the WTP threshold standard. These three active screening strategies all had cost utility advantages. Conclusion: As an economic and effective public health intervention measure，continuous active screening for close contacts has high cost-effectiveness value. |
| Key words: pulmonary tuberculosis close contacts active case finding passive case finding cost-effectiveness analysis |
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